What determines a country's proactiveness during a pandemic?

What determines a country's proactiveness during a pandemic? The answer to the question lies the focus of this article. This study attempted to determine the extent to which Hofstede's national cultural dimensions are associated with a country's proactiveness. Proactiveness is about acting in advance for the desired outcome(s). The present study accounted for the country's proactiveness as the number of tests conducted per thousand people in the initial phase of the pandemic to prevent an outbreak. For this, data from 64 countries was used and found that cultural dimensions such as power distance, masculinity, and uncertainty avoidance influence a country's proactiveness in the pandemic outbreak's initial phase. Low power distance, low masculinity, and high uncertainty avoidance are related to increased proactiveness. National cultural dimensions explain approximately 66% of the variance in proactiveness. The study findings suggest that national culture influences a country's efforts during the pandemic, implying the need to consider the country's cultural orientation for the effective design and implementation of preventive measures. The theoretical and practical implications of the findings are discussed.

Probing the competitive inhibitor efficacy of frog-skin alpha helical AMPs identified against ACE2 binding to SARS-CoV-2 S1 spike protein as therapeutic scaffold to prevent COVID-19.

In COVID-19 infection, the SARS-CoV-2 spike protein S1 interacts to the ACE2 receptor of human host, instigating the viral infection. To examine the competitive inhibitor efficacy of broad spectrum alpha helical AMPs extracted from frog skin, a comparative study of intermolecular interactions between viral S1 and AMPs was performed relative to S1-ACE2p interactions. The ACE2 binding region with S1 was extracted as ACE2p from the complex for ease of computation. Surprisingly, the Spike-Dermaseptin-S9 complex had more intermolecular interactions than the other peptide complexes and importantly, the S1-ACE2p complex. We observed how atomic displacements in docked complexes impacted structural integrity of a receptor-binding domain in S1 through conformational sampling analysis. Notably, this geometry-based sampling approach confers the robust interactions that endure in S1-Dermaseptin-S9 complex, demonstrating its conformational transition. Additionally, QM calculations revealed that the global hardness to resist chemical perturbations was found more in Dermaseptin-S9 compared to ACE2p. Moreover, the conventional MD through PCA and the torsional angle analyses indicated that Dermaseptin-S9 altered the conformations of S1 considerably. Our analysis further revealed the high structural stability of S1-Dermaseptin-S9 complex and particularly, the trajectory analysis of the secondary structural elements established the alpha helical conformations to be retained in S1-Dermaseptin-S9 complex, as substantiated by SMD results. In conclusion, the functional dynamics proved to be significant for viral Spike S1 and Dermaseptin-S9 peptide when compared to ACE2p complex. Hence, Dermaseptin-S9 peptide inhibitor could be a strong candidate for therapeutic scaffold to prevent infection of SARS-CoV-2.

Young adults' experiences with loss and grief during COVID-19.

In the wake of the COVID-19 pandemic, people are experiencing unprecedented cumulative loss and grief. Guided by life course theory, we used inductive qualitative analysis and explored young adults' (N = 86) written accounts of their earliest and most significant losses associated with COVID-19, as well as their coping mechanisms. Overall, participants experienced substantial loss, especially losses related to their education and social life/events. We discuss five subthemes related to approaches to coping and five subthemes related to barriers to coping. Our findings are relevant to informing strategies that support adapting to significant loss in early adulthood, beyond the pandemic.